HEMPY hemp seed oil CBD- Scientific evidences

HEMP SEED OIL AND SKIN HEALTH

THE PERMEABILITY BARRIER IN ESSENTIAL FATTY ACID DEFICIENCY: EVIDENCE FOR A DIRECT ROLE FOR LINOLEIC ACID IN BARRIER FUNCTION. THE JOURNAL OF INVESTIGATIVE DERMATOLOGY, PETER M. ELIAS, BARBARA E. BROWN, AND VINCENT A. ZIBOH.74:230-233, 1980
https://www.sciencedirect.com/science/article/pii/S0022202X1545763X

THE AMELIORATIVE EFFECT OF HEMP SEED HEXANE EXTRACTS ON THE PROPIONIBACTERIUM ACNESINDUCED INFLAMMATION AND LIPOGENESIS IN SEBOCYTES
https://www.ncbi.nlm.nih.gov/pubmed/30148860
EFFICACY OF DIETARY HEMPSEED OIL IN PATIENTS WITH ATOPIC DERMATITIS. CALLAWAY J, SCHWAB U, HARVIMA I ET AL. J DERMATOLOG TREAT. 2005 APR;16(2):87-94.
https://www.ncbi.nlm.nih.gov/pubmed/16019622

OMEGA-3 VERSUS OMEGA-6 POLYUNSATURATED FATTY ACIDS IN THE PREVENTION AND TREATMENT OF INFLAMMATORY SKIN DISEASES. ANAMARIA BALI´C ET AL. INT. J. MOL. SCI. 2020, 21, 741;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037798/

EFFECT OF DIETARY SUPPLEMENTATION WITH OMEGA-3 FATTY ACID AND GAMMA-LINOLENIC ACID ON ACNE VULGARIS: A RANDOMISED, DOUBLEBLIND, CONTROLLED TRIAL. JAE YOON JUNG ET AL. ACTA DERM VENEREOL 2014; 94: 521–525
https://www.ncbi.nlm.nih.gov/pubmed/24553997

BENEFITS OF THE BALANCED OMEGA 6/OMEGA 3 RATIO

P SIMOPOULOS. THE IMPORTANCE OF THE RATIO OF OMEGA-6/OMEGA-3 ESSENTIAL FATTY ACIDS. BIOMEDICINE & PHARMACOTHERAPY. VOLUME 56, ISSUE 8, OCTOBER 2002, PAGES 365-379
https://www.sciencedirect.com/science/article/abs/pii/S0753332202002536
KRISTIAN SOBORG HUSTED, ELENA V. BOUZINOVA. THE IMPORTANCE OF N-6/N-3 FATTY ACIDS RATIO IN THE MAJOR DEPRESSIVE DISORDER. MEDICINA 52 (2016) 139-147
https://www.sciencedirect.com/science/article/pii/S1010660X16300210
EVOLUTIONARY ASPECTS OF DIET, THE OMEGA-6/OMEGA-3 RATIO AND GENETIC VARIATION: NUTRITIONAL IMPLICATIONS FOR CHRONIC DISEASES. A.P SIMOPOULOS. BIOMEDICINE & PHARMACOTHERAPY 60 (2006) 502–507
https://www.ncbi.nlm.nih.gov/pubmed/17045449
MULTI-OMIC ANALYSIS IN TRANSGENIC MICE IMPLICATES OMEGA-6/OMEGA-3 FATTY ACID IMBALANCE AS A RISK FACTOR FOR CHRONIC DISEASE. KANAKARAJU KALIANNAN ET AL. COMMUNICATIONS BIOLOGY | (2019) 2:276
https://www.ncbi.nlm.nih.gov/pubmed/31372515
DIETARY INTAKE OF N23 AND N26 FATTY ACIDS AND THE RISK OF CLINICAL DEPRESSION IN WOMEN: A 10-Y PROSPECTIVE FOLLOW-UP STUDY. MICHEL LUCAS ET AL. AM J CLIN NUTR 2011;93:1337–43
https://www.researchgate.net/publication/51030594_Dietary_intake_of_n-3_and_n-6_fatty_acids_and_the_risk_of_clinical_depression_in_women_A_10-y_prospective_follow-up_study
METABOLISM OF OMEGA-6 POLYUNSATURATED FATTY ACIDS IN WOMEN WITH DYSMENORRHEA. CHAO-CHIH WU MSC ET AL. ASIA PAC J CLIN NUTR 2008;17 (S1):216-219 https://www.ncbi.nlm.nih.gov/pubmed/18296341
EFFECT OF OMEGA-3 FATTY ACIDS ON INTENSITY OF PRIMARY DYSMENORRHEA. NAHID RAHBAR, NEDA ASGHARZADEH, RAHEB GHORBANI. INTERNATIONAL JOURNAL OF GYNECOLOGY AND OBSTETRICS, 2011
https://www.ncbi.nlm.nih.gov/pubmed/22261128

THE ROLE OF ESSENTIAL FATTY ACIDS AND PROSTAGLANDINS IN THE PREMENSTRUAL SYNDROME. HORROBIN DF. J REPROD MED. 1983 JUL;28(7):465-8
https://www.ncbi.nlm.nih.gov/pubmed/6350579

BENEFITS FOR CARDIOVASCULAR DISEASES AND HYPERCHOLESTEROL

THE CARDIAC AND HAEMOSTATIC EFFECTS OF DIETARY HEMPSEED. DELFIN RODRIGUEZ-LEYVA AND GRANT N PIERCE. NUTR METAB (LOND). 2010
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868018/

ASSOCIATION BETWEEN DIETARY ARGININE AND C-REACTIVE PROTEIN. WELLS BJ, MAINOUS AG 3RD, EVERETT CJ. NUTRITION. 2005 FEB;21(2):125-30.
https://www.ncbi.nlm.nih.gov/pubmed/15723738

SEMI E OLIO DI SEMI DI CANAPA- NUTRIZIONE E MEDICINA, MELOSINI.2016
https://www.researchgate.net/publication/308169214_Semi_e_Olio_di_Canapa_-_Nutrizione_e_Medicina

CHOLESTEROL-INDUCED STIMULATION OF PLATELET AGGREGATION IS PREVENTED BY A HEMPSEED-ENRICHED DIET. PROCIUK MA, EDEL AL ET AL. CAN J PHYSIOL PHARMACOL. 2008 APR;86(4):153-9.
https://pubmed.ncbi.nlm.nih.gov/18418423/
ATHEROPROTECTIVE EFFECTS OF CONJUGATED LINOLEIC ACID. BRUEN R, FITZSIMONS S, BELTON O. BR J CLIN PHARMACOL. 2017 JAN;83(1):46-53.
https://pubmed.ncbi.nlm.nih.gov/27037767/

BENEFITS OF BALANCED INTAKE OF OMEGA 3/OMEGA 6 FOR BRAIN HEALTH AND FUNCTIONALITY

EFFECTS OF N-3 POLYUNSATURATED FATTY ACIDS ON DEMENTIA. https://www.ncbi.nlm.nih.gov/pubmed/27924168
EFFECTS OF DIETARY ALPHA-LINOLENIC ACID DEFICIENCY ON NEUROMUSCULAR AND COGNITIVE FUNCTIONS IN MICE https://www.ncbi.nlm.nih.gov/pubmed/7475943
LIFELONG IMBALANCED LA/ALA INTAKE IMPAIRS EMOTIONAL AND COGNITIVE BEHAVIOR VIA CHANGES IN BRAIN ENDOCANNABINOID SYSTEM. https://www.ncbi.nlm.nih.gov/pubmed/27903595
OMEGA-6/OMEGA-3 RATIO AND COGNITION IN CHILDREN WITH EPILEPSY https://www.ncbi.nlm.nih.gov/pubmed/30660389
INTERPLAY BETWEEN N‑3 AND N‑6 LONG‑CHAIN POLYUNSATURATED FATTY ACIDS AND THE ENDOCANNABINOID SYSTEM IN BRAIN PROTECTION AND REPAIR. LIPIDS SIMON C. DYALL ET AL (2017) 52:885–900
https://pubmed.ncbi.nlm.nih.gov/28875399/
ALPHA-LINOLENIC ACID: AN OMEGA-3 FATTY ACID WITH NEUROPROTECTIVE PROPERTIES: READY FOR USE IN THE STROKE CLINIC? NICOLAS BLONDEAU ET AL. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY · OCTOBER 2014
https://pubmed.ncbi.nlm.nih.gov/25789320/

ALPHA-LINOLENIC ACID, A NUTRACEUTICAL WITH PLEIOTROPIC PROPERTIES THAT TARGETS ENDOGENOUS NEUROPROTECTIVE PATHWAYS TO PROTECT AGAINST ORGANOPHOSPHATE NERVE AGENT-INDUCED NEUROPATHOLOGY. TETSADE PIERMARTIRI ET AL. MOLECULES 2015, 20, 20355–20380;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332275/

CANNABIDIOL- SCIENTIFIC LITERATURE

CANNABIDIOL – RECENT ADVANCES. RAPHAEL MECHOULAM*A), MAXIMILIAN PETERSA), ERIC MURILLO-RODRIGUEZB), AND LUM”R O. HANUSˇ A) CHEMISTRY & BIODIVERSITY – VOL. 4 (2007)
https://www.ncbi.nlm.nih.gov/pubmed/17712814
THE THERAPEUTIC POTENTIAL OF CANNABIS AND CANNABINOIDS, FRANJO GROTENHERMEN, DR. MED.1 AND KIRSTEN MÜLLER-VAHL, PROF. DR. MED.*,2 DTSCH ARZTEBL INT. 2012 JUL; 109(29-30)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442177/
SAFETY AND SIDE EFFECTS OF CANNABIDIOL – A REVIEW OF CLINICAL DATA AND RELEVANT ANIMAL STUDIES KERSTIN IFFLAND (B.SC. BIOMEDICINE, M.SC. NEUROSCIENCE) AND DR. MED. FRANJO GROTENHERMEN, NOVA-INSTITUT (WWW.NOVA-INSTITUT.EU) HÜRTH (GERMANY), OCTOBER 2016 EUROPEAN INDUSTRIAL HEMP ASSOCIATION (EIHA)
https://www.ncbi.nlm.nih.gov/pubmed/?term=Safety+and+Side+Effects+of+Cannabidiol+%E2%80%93+A+review+of+clinical+data+and+relevant+animal+studies
AN UPDATE ON SAFETY AND SIDE EFFECTS OF CANNABIDIOL: A REVIEW OF CLINICAL DATA AND RELEVANT ANIMAL STUDIES KERSTIN IFFLAND* AND FRANJO GROTENHERMEN PUBLISHED ONLINE 2017 JUN 1. CANNABIS CANNABINOID RES. 2017; 2(1): 139–154
https://www.ncbi.nlm.nih.gov/pubmed/?term=An+Update+on+Safety+and+Side+Effects+of+Cannabidiol%3A+A+Review+of+Clinical+Data+and+Relevant+Animal+Studies
SAFETY AND SIDE EFFECTS OF CANNABIDIOL, A CANNABIS SATIVA CONSTITUENT MATEUS MACHADO BERGAMASCHI, REGINA HELENA COSTA QUEIROZ1, ANTONIO WALDO ZUARDI2 AND, JOSÉ ALEXANDRE S. CRIPPA*,2 CURRENT DRUG SAFETY, 2011, 6, 237-249
https://www.ncbi.nlm.nih.gov/pubmed/22129319
CANNABINOIDS AS NOVEL ANTI-INFLAMMATORY DRUGS. PRAKASH NAGARKATTI, RUPAL PANDEY, SADIYE AMCAOGLU RIEDER, VENKATESH L HEGDE & MITZI NAGARKATTI. FUTURE MEDICINAL CHEMISTRY, VOL 1, NO 7.
https://www.ncbi.nlm.nih.gov/pubmed/20191092
THE ENDOCANNABINOID SYSTEM OF THE SKIN IN HEALTH AND DISEASE: NOVEL PERSPECTIVES AND THERAPEUTIC OPPORTUNITIES. TAMÁS BÍRÓ BALÁZS I.TÓTH GYÖRGY HASKÓ RALF PAUS PÁL PACHER. TRENDS IN PHARMACOLOGICAL SCIENCES VOLUME 30, ISSUE 8, AUGUST 2009, PAGES 411-420
https://www.ncbi.nlm.nih.gov/pubmed/?term=The+endocannabinoid+system+of+the+skin+in+health+and+disease%3A+novel+perspectives+and+therapeutic+opportunities.
THE ROLE OF CANNABINOIDS IN DERMATOLOGY. JESSICA S. MOUNESSA BS JULIA A. SIEGEL BA,CORY A.DUNNICKMD ROBERT P.DELLAVALLEMD, PHD, MSPH. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. VOLUME 77, ISSUE 1, JULY 2017, PAGES 188-190
https://www.ncbi.nlm.nih.gov/pubmed/28416341
CANNABINOIDS INHIBIT HUMAN KERATINOCYTE PROLIFERATION THROUGH A NON-CB1/CB2 MECHANISM AND HAVE A POTENTIAL THERAPEUTIC VALUE IN THE TREATMENT OF PSORIASIS. WILKINSON JD, WILLIAMSON EM. J DERMATOL SCI. 2007 FEB;45(2):87-92.
https://www.ncbi.nlm.nih.gov/pubmed/?term=Cannabinoids+inhibit+human+keratinocyte+proliferation+through+a+non-CB1%2FCB2+mechanism+and+have+a+potential+therapeutic+value+in+the+treatment+of+psoriasis
CANNABIDIOL CLAIMS AND MISCONCEPTIONS. RUSSO, E.B., TRENDS IN PHARMACOLOGICAL SCIENCES, 2017. 38(3): P. 198-201.
https://www.ncbi.nlm.nih.gov/pubmed/28089139
Cannabidiol as an Emergent Therapeutic Strategy for Lessening the Impact of Inflammation on Oxidative Stress. George W. Booz. NIH Public Access. Free Radic Biol Med. 2012.

TREATMENT OF PAIN

Cannabinoids in Pain Management and Palliative Medicine. Winfried Häuser, Mary-Ann Fitzcharles, Lukas Radbruch, Frank Petzke. Dtsch Arztebl Int 2017; 114: 627–34 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645627/
Is cannabis an effective treatment for joint pain? R.J. Miller, R.E. Miller. Clinical and Experimental Rheumatology 2017. https://www.ncbi.nlm.nih.gov/pubmed/28967368
CANNABINOIDS IN THE MANAGEMENT OF DIFFICULT TO TREAT PAIN. ETHAN B RUSSO. THER CLIN RISK MANAG. 2008 FEB; 4(1): 245–259.
https://www.ncbi.nlm.nih.gov/pubmed/18728714

CBD IN RHEUMATOLOGY

Efficacy, tolerability and safety of cannabinoids in chronic pain associated with rheumatic diseases (fibromyalgia syndrome, back pain, osteoarthritis, rheumatoid arthritis). M.-A. Fitzcharles, C. Baerwald · J. Ablin · W. Häuser. Schwerpunkt. 2016 https://www.ncbi.nlm.nih.gov/pubmed/26767993
Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Holly T. Philpott, Melissa O’Brien, Jason J. McDougall. Research paper pain. 2017 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690292/

CBD IN NEUROLOGY

In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer’s Disease. Georgia Watt and Tim Karl. Frontiers in pharmacology. 2017 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289988/
The neuroprotection of cannabidiol against MPP+-induced toxicity in PC12 cells involves trkA receptors, upregulation of axonal and synaptic proteins, neuritogenesis, and might be relevant to Parkinson’s disease. Neife Aparecida Guinaim Santos, Nádia Maria Martins et al. Toxicology in Vitro 30 (2015) 231–240
https://www.sciencedirect.com/science/article/pii/S0887233315300047
Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Orrin Devinsky, Maria Roberta Cilio, Helen Cross, et al. HHS Public Access. 2014 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707667/
Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Orrin Devinsky, Eric Marsh, Daniel Friedman. Lancet Neurol 2016; 15: 270–78. https://www.ncbi.nlm.nih.gov/pubmed/26724101
CANNABINOIDS AND EPILEPSY. EVAN C. ROSENBERG, RICHARD W. TSIEN, BENJAMIN J. WHALLEY, AND ORRIN DEVINSKY. NEUROTHERAPEUTICS. 2015 OCT; 12(4): 747–768.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604191/
ANTICONVULSANT EFFECTS OF THE (–) AND (+)ISOMERS OF CANNABIDIOL AND THEIR DIMETHYLHEPTYL HOMOLOGS. LEITE, J., ET AL., VOL. 24. 1982. 141-6.
https://www.ncbi.nlm.nih.gov/pubmed/?term=Anticonvulsant+Effects+of+the+(%E2%80%93)+and+(%2B)Isomers+of+Cannabidiol+and+Their+Dimethylheptyl+Homologs

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